Over the years, medical science has been continuously evolving to accommodate any changes in the medical landscape. It does not cease from looking for solutions and treatments of various diseases. The discovery of liposome is among the most remarkable breakthroughs in the industry. This is used to aid drug intake to enhance its efficiency, increase success rate in organ transplant surgery and treat several medical malfunctions.
Liposomes are microscopical vesicles developed in an artificial environment like a laboratory. These are composed of phospholipids that are naturally produced or extracted from another source. Its outer wall has similar composition to that of a cell wall. This allows direct interaction between the cells and the liposomes. These tiny, spheroid-shaped bubbles are typically watery in its core.
The most common use of this structure is to introduce medicines to the patient’s body more effectively. The unique property of the vesicles allow drugs to be delivered in specific parts of the body through diffusion. With its double-layered membranes, the vesicle can carry hydrophobic drugs. This can also be used to carry biological agents like antibodies to targeted parts in the patient’s body.
Furthermore, this helps extend the transfer time of the medicines. The double-layered spheres slowly transmits the drugs in interval for a period of time so the body can take it in gradually. This and the ability to direct its target make this a perfect choice in reducing the medicines’ side-effects and enhance its potency.
The vesicles are also believed to be an effective cancer fighting agent. The spheroids can mark the cancer cells. It can also slip right to the tumor by going through the blood flow. This stays in the bloodstreams as well because of its miniature size and its property that is similar to the blood vessels. The drug vessels cannot pass through the endothelial wall as opposed to cancer cells, which are naturally leaky.
Autoimmune diseases may also be combated by using the spheroids. In a transplant surgery, the body usually identifies the newly harvested organ to be a foreign entity. The body’s natural protection, the immune system, may attack the organ in an attempt to prevent possible infestation. This could lead to transplant rejection. The artificial lipid is used to suppress the function of the immune system and slow down its progress.
However, this drug vessel is not spontaneously produced. There are many different methods to create the vesicles depending on its function and purpose. The methods of dissemination and the conditions in which it will be released must be taken into account. The type of material to be transported determines how the structure is created.
The vesicles can be produced in varying sizes. Typically, these are developed small enough so the white blood cells can easily engulf it before releasing the drug it carries. Decision has to be made before production to know the size and number of vesicles to be produced. If there is a need, reproduction must also be considered.
One reservation for medical practitioners regarding this extremely useful breakthrough is its production costs. Mass production is currently unavailable since the vessels cannot last long after its creation. There has been cases of instability and unintentional mixture of drugs as well. Other than that, liposome is definitely a promising discovery.
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